It has a role as an astringent, a cyclooxygenase 2 inhibitor, a plant metabolite, an antioxidant, an antineoplastic agent, a human xenobiotic metabolite, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor and an apoptosis inducer.It is a conjugate acid of a gallate. Gallic acid (3, 4, 5-trihydroxybenzoic acid), a naturally occurring polyphenolic antioxidant is a key component of beverages and food. Gallic acid (also known as 3,4,5-trihydroxybenzoic acid) is a trihydroxybenzoic acid, a type of phenolic acid, found in gallnuts, sumac, witch hazel, tea leaves, oak bark, and other plants. Gallic acid is used a remote astringent in cases of internal haemorrhage. 3,4,5-trihydroxybenzoic acid hydrate. Gallic acid (anhydrous) for synthesis. Contents. 2004-09-16. Materials. The solubility of gallic acid in methanol, ethanol, water, and ethyl acetate was measured at a temperature range of (298.2 to 333.2) K. The gallic acid solubility in different solvents increases smoothly with temperature. Występowanie. It is a conjugate acid of a digallate. Gallic acid, substance occurring in many plants, either in the free state or combined as gallotannin.It is present to the extent of 40–60 percent combined as gallotannic acid in tara (any of various plants of the genus Caesalpinia) and in Aleppo and Chinese galls (swellings of plant tissue), from which it is obtained commercially by the action of acids or alkalies. Eating these foods and taking in gallic acid supplements can protect the heart and brain, and enhance the immune system. Gallic acid Sigma, USA was used to prepare conjugates. Definition: A benzoate ester that is any ester resulting from the formal condensation of the carboxy group of gallic acid (3,4,5-trihydroxybenzoic acid) with an alcoholic or phenolic hydroxy group. Gallic acid (anhydrous) for synthesis. Digallic acid is a benzoate ester and a gallate ester. CAS 149-91-7, molar mass 170.12 g/mol. It has been shown to exhibit numerous biological and pharmacological properties, including antiviral, antibacterial, and antitumor activities in numerous human cancer cell lines. Gallic acid possesses antioxidant, antifungal, antiviral, anticancer activities [1-3]. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells. B. Reade towards the end of March 1839. Gallic acid is a trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5. ChEBI. (+)-epicatechin-3-O-gallate Mass: 442.37230 Gallic acid 3-monogallate. Gallic acid - wchodzi w skład garbników, czyli związków fenolowych. 95 Gallic acid has been shown to effectively suppress DSS-induced colitis in mice. In vitro Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. To determine whether gallic acid had a time-dependent effect on the cervical cancer cells, the cells were treated with concentrations of 0, 10, 12.5 or 15 μg/ml, and an MTT assay was performed at 24, 48, 72 and 96 h ().Gallic acid was able to induce significant inhibition of cell proliferation in the HeLa and HTB-35 cells, but only in a dose-dependent manner. 2020-12-12. His “hopes of the gallate of silver” were communicated to W. H. F. Talbot in a letter of 28 February and indirectly through J. Enzyme preparation. Due to its poor lipophilic property, the application of gallic acid in functional food and medicine is restricted. - Find MSDS or SDS, a COA, data sheets and more information. m-Galloylgallic acid. Uses and Facts. Silver nitrate and ammonium hydroxide Fisher Scientific, USA were used to synthesize AgNPs. Ascorbic acid, gallic acid were procured from Sigma-Aldrich (Bangalore, India), HPLC grade methanol, acetonitrile and water were purchased from J.T. Ungraded products supplied by Spectrum are indica Gallic Acid, Anhydrous, also known as 3,4,5-trihydroxybenzoic acid, is a type of phenolic acid that is found in sumac, gallnuts and tea leaves, and is used in the pharmaceutical industry. Gallic acid fails to attenuate isoproterenol-induced myocytolysis. Dates: Modify . Gallic acid and its derivatives are present in nearly every part of the plant, such as bark, wood, leaf, fruit, root, and seed. Gallic acid is … The relative solubility of gallic acid in the solvents was found as: wmethanol > wethanol > wwater > wethyl acetate. Plik Gallic acid.svg znajduje się w Wikimedia Commons – repozytorium wolnych zasobów. Gallicacidmonohydrate Gallic acid is a phenolic compound also known as 3,4,5-trihydroxybenzoic acid. Standard preparation Ascorbic and galllic acid … Stars This entity has been manually annotated by the ChEBI Team. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. 3,4,5-Trihydroxybenzoic acid monohydrate. 5995-86-8. Usage : Gallic acid is mainly used as a synthetic intermediate for the production of pyrogallol and gallic acid esters used in the food and pharmaceutical industries (Deschamps and Lebeault, 1984). gallic acid: ChEBI ID CHEBI:30778: Definition A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5. Kwas galusowy jest składnikiem liści herbaty. Gallic acid is found both free and as part of hydrolyzable tannins.. Gallic acid is commonly used in the pharmaceutical industry.. Gallic acid is used as a remote astringent in cases of internal haemorrhage.. Gallic acid is also used to treat albuminuria and diabetes.. Gallic acid is a component of some pyrotechnic whistle mixtures.. Gallic acid is found in a number of land plants. Gallic acid is an organic acid found in foods such as blueberries, apples, flaxseeds, tea leaves, oak bark, walnuts and watercress. It is found both as a free state and as a constituent of tannins, namely, gallotannin. [citation needed] The chemical formula of gallic acid is C 6 H 2 3 COOH.It is found both free and as part of hydrolyzable tannins.The gallic acid groups are usually bonded to form dimers such as ellagic acid. - Find MSDS or SDS, a COA, data sheets and more information. Create . Discusses the earliest use of gallic acid, important as the first photographic developer. Copper acetate anhydrous (Cu(CH 3 COO) 2), gallic acid (GA), tannin acid (TA), and 3,3′,5,5′-tetramethy benzidine (TMB) were purchased from Sigma-Aldrich (St. Louis, MO, U.S.A.). W chińskiej herabcie, rdest. More... Molecular Weight: 322.22 g/mol. Gallic acid, deuterium oxide (D 2 O), 1,1-diphenyl-2-picrylhydrazyl (DPPH), 3-(3,4-dihydroxylphenyl)-l-alanine (l-DOPA), mushroom tyrosinase, and β-arbutin were obtained from Sigma-Aldrich (St. Louis, MO, USA).All chemical reagents were commercially available and of analytical reagent grade. Gallic acid, 3, 4, 5-trihydroxybenzoic acid can be found in gallnuts, sumac, witch hazel, tea leaves, oak bark, etc. Structure, properties, spectra, suppliers and links for: Gallic acid, 149-91-7. It is used in the pharmaceutical industry as a standard for determining the phenol content (a large group of several hundred chemical substances) of various analytes by the Folin-Ciocalteau assay. Gallic acid monohydrate. Znajdziemy go m.in. Its supplements are available as capsules, ointments and liquid extracts, and have been used traditionally to treat a variety of ailments. In first week of February 1839, John Herschel introduced gallic acid into photographic science. Gallic acid is an antioxidant which can inhibit both COX-2. Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs. Dane z jego strony opisu znajdują się poniżej. The Folin-Chocalteu reagent Merck, USA was used to determine the amount of polyphenol in the final compound. 1 Structures Expand this section. CAS 149-91-7, molar mass 170.12 g/mol. Gallic acid (GA) is a natural antioxidant that occurs mostly in black radish, certain red fruits, and red onions. Glacial acetic acid was purchased from Merck (Mumbai, India). Gallic acid, chemical formula – C6H2(OH)3CO2H – is an acid found in many plants and acts as an antioxidant, helping to protect our cells against oxidative damage.. Gallic acid [3,4,5-trihydroxybenzoic acid (GA)], a natural phytochemical, is known to have a variety of cellular functions including beneficial effects on metabolic syndromes. Gallic acid is a helpful organic acid that can be found in many popular foods such as blueberries and watercress. After 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Changes of the content of gallic acid from Cornus fructus after soaking with each solvent ratio (ethanol 20, 40, 50, 60, 70, 80, and 100%) for 12, 24, and 48 hr, respectively. Kwas galusowy występuje w wielu roślinach zarówno w stanie wolnym, jak również w postaci galotaniny.Kwas ten zawiera na przykład ziele żurawki, jak również liść i kora oczaru.W roślinach z rodzaju brezylka (Caesalpinia) oraz w galasach występuje w postaci kwasu galusowo-taninowego. Gallic acid (3,4,5-trihydroxybenzoic acid), thiobarbituric acid (TBA), high melting point agarose and low melting point agarose were procured from Sigma-Aldrich, Inc., St Louis, MO, USA. 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